Products for Research Use Only
RegisterLogin

SRI-31255

CAT: 0804-HY-75368-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-75368-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SRI-31255 is an orally active LRRK2 inhibitor with IC50 values of 520 and 427 nM for human wild-type (WT) and mutant G2019S, respectively. SRI-31255 exerts neuroprotective effects by binding to the ATP-binding pocket of LRRK2, inhibiting kinase activity. SRI-31255 can be used as a lead compound for the development of LRRK2-targeted drugs for the treatment of Parkinson's disease[1].
CAS Number
905580-86-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
LRRK2
Related Pathways
Autophagy
Field of Research
Neurological Disease
Smiles
C1(N[C@@H](CC2)C3=C2C=CC=C3)=C4C(NC=C4)=NC=N1
Molecular Formula
C15H14N4
Molecular Weight
250.30
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Moukha-Chafiq O, et al. Discovery of a Chiral 2,4-Substituted Pyrrolo[2,3-d]pyrimidine as a Potent, Selective, and Orally Bioavailable LRRK2 Inhibitor. J Med Chem. 2025 May 22;68 (10) :9926-9946.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported

Related Products

CatalogName
HY-114363SRI 31215
HY-114363A-01SRI 31215 (TFA)
HY-175535SRI-32743
HY-175661SRI-22136
HY-117002-01SRI 37892
HY-148853-01SRI-42127
HY-165543SRI-29132
HY-100347-01SRI-011381
HY-160783-01SRI-43265
HY-123600-01SRI-29329

Alternative Products

CatalogName
T207344-01SRI-31255
CSB-CL022665HUSRI
BA4890-5SRI-43265
BA6623-100SRI-37240
BA6616-100SRI-41315
70R-20520SRI antibody
T210311-01SRI-31142
T73286-01SRI-42127
T34706-01SRI-29132
T28852-01SRI-31040

Popular Products