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Azeliragon-d9

CAT: 0804-HY-50682SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-50682SSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Azeliragon-d9 (TTP488-d9) is the deuterium labeled Azeliragon. Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD). Azeliragon also can cross the blood-brain barrier (BBB).
Product Name Alternative
TTP488-d9; PF-04494700-d9
UNSPSC
12352005
Target
Amyloid-β; Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling; Others
Field of Research
Endocrinology; Neurological Disease
Smiles
[2H]C([2H])(C([2H])(C([2H])(C([2H])(C1=NC(C2=CC=C(C=C2)OCCCN(CC)CC)=CN1C3=CC=C(C=C3)OC4=CC=C(C=C4)Cl)[2H])[2H])[2H])[2H]
Molecular Formula
C32H29D9ClN3O2
Molecular Weight
541.17
References & Citations
[1]Burstein AH, et al. Assessment of Azeliragon QTc Liability Through Integrated, Model-Based Concentration QTc Analysis. Clin Pharmacol Drug Dev. 2019 May;8 (4) :426-435. |[2]Bongarzone S, et al. Targeting the Receptor for Advanced Glycation Endproducts (RAGE) : A Medicinal Chemistry Perspective. J Med Chem. 2017 Sep 14;60 (17) :7213-7232.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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