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Azeliragon

CAT: 0804-HY-50682-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-50682-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD) [1]. Azeliragon also can cross the blood-brain barrier (BBB) [2].
CAS Number
603148-36-3
Product Name Alternative
TTP488; PF-04494700
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Azeliragon.html
Purity
99.75
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C=C1)OC2=CC=C(C=C2)N3C(CCCC)=NC(C(C=C4)=CC=C4OCCCN(CC)CC)=C3
Molecular Formula
C32H38ClN3O2
Molecular Weight
532.12
Precautions
H302, H315, H319, H335
References & Citations
[1]Burstein AH, et al. Assessment of Azeliragon QTc Liability Through Integrated, Model-Based Concentration QTc Analysis. Clin Pharmacol Drug Dev. 2019 May;8 (4) :426-435.|[2]Bongarzone S, et al. Targeting the Receptor for Advanced Glycation Endproducts (RAGE) : A Medicinal Chemistry Perspective. J Med Chem. 2017 Sep 14;60 (17) :7213-7232.|[3]Chen Y, et al. RAGE ligation affects T cell activation and controls T cell differentiation. J Immunol. 2008 Sep 15;181 (6) :4272-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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BA8408-10Azeliragon
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