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5-CNAC

CAT: 0804-HY-401721-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-401721-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-CNAC is an orally active enhancer of absorption, with no pharmacological activity on its own. 5-CNAC can significantly enhance the absorption efficiency of the drug (such as salmon calcitonin) when administered together with it in the gastrointestinal tract. 5-CNAC binds reversibly and non-covalently to peptide drugs, protecting them from degradation by gastrointestinal enzymes, increasing their lipid solubility, promoting passive transcellular absorption, and not damaging the integrity of the intestinal epithelium. 5-CNAC can be used in the research of adjuvants for orally administered peptide agents[1][2].
CAS Number
204852-67-5
UNSPSC
12352005
Target
Others
Related Pathways
Others
Field of Research
Others
Purity
99.49
Smiles
O=C(O)CCCCCCCNC(C1=CC(Cl)=CC=C1O)=O
Molecular Formula
C15H20ClNO4
Molecular Weight
313.78
References & Citations
[1]Hamdy RC, Daley DN. Oral calcitonin. Int J Womens Health. 2012;4:471-9.|[2]Gschwind HP, et al. Metabolism and disposition of the oral absorption enhancer 14C-radiolabeled 8- (N-2-hydroxy-5-chlorobenzoyl) -amino-caprylic acid (5-CNAC) in healthy postmenopausal women and supplementary investigations in vitro. Eur J Pharm Sci. 2012 Aug 30;47 (1) :44-55.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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