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C2 Phytoceramide (t18:0/2:0)

CAT: 0931-T36671Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T36671Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Bioactivity
C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 μM) in suspended polymorphonuclear cells. It increases COX-2 protein levels 15-fold through ERK signaling. It induces death of keratinocytes (20% viability) with an ED50 value of 30 μM, the same concentration at which 35% of cells in a TUNEL assay are apoptotic. C2 Phytoceramide also has antiproliferative effects in CHO cells, with greater than 80% cytotoxicity achieved at a concentration of 20 μM, and induces internucleosomal DNA fragmentation. In addition, it inhibits the activation of phospholipase D (PLD) mediated by muscarinic acetylcholine receptors in vitro.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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