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Solabegron-d8

CAT: 0804-HY-19436SSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19436SSize:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Solabegron-d8 (GW 427353-d8) is deuterium labeled Solabegron. Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM[1]. Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome[1].
CAS Number
[1250988-09-0]
Product Name Alternative
GW 427353-d8
UNSPSC
12352101
Target
Adrenergic Receptor; Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Endocrinology
Smiles
O=C(O)C1=C(C(C2=C(C([2H])=C(C(NCCNC[C@H](O)C3=CC=CC(Cl)=C3)=C2[2H])[2H])[2H])=C(C([2H])=C1[2H])[2H])[2H]
Molecular Formula
C23H15D8ClN2O3
Molecular Weight
418.94
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Hicks A, et al. GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. J Pharmacol Exp Ther. 2007 Oct;323 (1) :202-9.|[3]Andersson KE, et al. Selective β3-adrenoceptor agonists for the treatment of overactive bladder. J Urol. 2013 Oct;190 (4) :1173-80.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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