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RB-105

CAT: 0804-HY-19200Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19200Size:1 Each
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Description
RB-105 is an inhibitor of angiotensin-converting enzyme (ACE) (Ki = 4.2 nM) and neutral endopeptidase (NEP) (Ki = 1.7 nM) . RB-105 after inhibiting ACE reduces the production of Ang II and increase the level of bradykinin. RB-105 after inhibiting NEP increases the level of natriuretic peptide and further increases the level of bradykinin, thereby generating a powerful synergistic effect. RB-105 has significant antihypertensive and natriuretic effects in both spontaneously hypertensive rats and normal blood pressure rats. RB-105 can be used for research on hypertension[1].
CAS Number
155895-89-9
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; Neprilysin
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
C[C@@H](C(O)=O)NC([C@@H](CS)[C@H](C1=CC=CC=C1)C)=O
Molecular Formula
C14H19NO3S
Molecular Weight
281.37
References & Citations
[1]Gonzalez Vera W, et al. Hypotensive and natriuretic effects of RB 105, a new dual inhibitor of angiotensin converting enzyme and neutral endopeptidase in hypertensive rats. J Pharmacol Exp Ther. 1995 Jan;272 (1) :343-51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ACE

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