SEN 78702

• Description :

  SEN 78702 is an orally active, selective, full α7 nAChR agonist, with a pEC50 of 6.13. SEN 78702 has an acceptable hERG inhibition (IC50: 15.8 μM) . SEN 78702 induces memory enhancement[1].

• UNSPSC :

  12352005

• Target :

  NAChR; Potassium Channel

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(NC1=CC(C2=CC(F)=CN=C2)=NN1)CCCN3CCCCC3

• Molecular Formula :

  C17H22FN5O

• Molecular Weight :

  331.39

• References & Citations :

  [1]Zanaletti R, et al. N-[5- (5-Fluoropyridin-3-yl) -1 H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775) : A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate[J]. Journal of Medicinal Chemistry, 2012, 55 (22) : 10277-10281.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1205530-63-7]