SEN 78702

CAT: 0804-HY-18176Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-18176Size:1 Each
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Description
SEN 78702 is an orally active, selective, full α7 nAChR agonist, with a pEC50 of 6.13. SEN 78702 has an acceptable hERG inhibition (IC50: 15.8 μM) . SEN 78702 induces memory enhancement[1].
CAS Number
[1205530-63-7]
UNSPSC
12352005
Target
NAChR; Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(NC1=CC(C2=CC(F)=CN=C2)=NN1)CCCN3CCCCC3
Molecular Formula
C17H22FN5O
Molecular Weight
331.39
References & Citations
[1]Zanaletti R, et al. N-[5- (5-Fluoropyridin-3-yl) -1 H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775) : A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate[J]. Journal of Medicinal Chemistry, 2012, 55 (22) : 10277-10281.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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