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WR 30090

CAT: 0804-HY-180373Size: 1 EachDry Ice: NoHazardous: No
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Description
WR 30090 (Compound 37) is a broad-spectrum antimalarial agent that does not rely on the classical antifolate pathway. WR 30090 exhibits strong activity against a variety of chloroquine-sensitive and resistant Plasmodium falciparum strains, especially the highly resistant Vietnamese strain. WR 30090 shows high activity in mouse malaria tests, with a minimum effective dose of 5 mg/kg and a minimum cure dose of 20 mg/kg. WR 30090 can be used for research on acute malaria[3][4][5].
CAS Number
19160-62-4
UNSPSC
12352005
Target
Parasite
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
ClC=1C=C(Cl)C2=NC(=CC(=C2C1)C(O)CN(CCCC)CCCC)C=3C=CC(Cl)=C(Cl)C3
Molecular Formula
C25H28Cl4N2O
Molecular Weight
514.31
References & Citations
[1]Genther CS, Smith CS. Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli. J Med Chem. 1977 Feb;20 (2) :237-43. |[2]Martin DC, et al. A quinoline methanol (WR 30090) for treatment of acute malaria. Antimicrob Agents Chemother. 1973 Feb;3 (2) :214-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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