WR-27653

• Description:

  WR-27653 (RC-12) is a derivative of Catechol with good activity against hypnozoites in the gold-standard Plasmodium cynomolgi-rhesus monkey (Macaca mulatta) model. WR-27653 has antimalarial activity[1][2].

• Product Name Alternative:

  RC-12

• UNSPSC:

  12352101

• Target:

  Drug Derivative; Parasite

• Related Pathways:

  Anti-infection; Others

• Field of Research:

  Infection

• Smiles:

  BrC1=C(N(CCN(CC)CC)CCN(CC)CC)C=C(OC)C(OC)=C1

• Molecular Formula:

  C20H36BrN3O2

• Molecular Weight:

  430.42

• References & Citations:

  [1]Werbel LM, et al. Synthesis and physical properties of the antimalarial agent 4- (2-bromo-4,5-dimethoxyphenyl) -1,1,7,7-tetraethyldiethylenetriamine (RC-12) (WR-27,653) . J Pharm Sci. 1967 Oct;56 (10) :1335-7. |[2]Dong Y, et al. Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12) . ACS Omega. 2022 Mar 30;7 (14) :12401-12411.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [6042-36-0]