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Cbz-QFR-kbt

CAT: 0804-HY-179708Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179708Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cbz-QFR-kbt is a ketone-based benzothiazole ketone inhibitor of TMPRSS2, with an IC50 value of 0.42 nM. Cbz-QFR-kbt also has inhibitory activity against Matriptase, Hepsin, HGFA, and Factor Xa, with IC50 values of 1, 1.3, 85, and 85 nM respectively. Cbz-QFR-kbt shows significant inhibitory effects against SARS-CoV-2 and H1N1 (IC50 = 60 nM) . Cbz-QFR-kbt can be used in antiviral research[1].
CAS Number
3086979-57-6
UNSPSC
12352005
Target
Factor Xa; Influenza Virus; SARS-CoV; Ser/Thr Protease
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
NC(NCCC[C@@H](C(C1=NC(C=CC=C2)=C2S1)=O)NC([C@H](CC3=CC=CC=C3)NC([C@H](CCC(N)=O)NC(OCC4=CC=CC=C4)=O)=O)=O)=N
Molecular Formula
C35H40N8O6S
Molecular Weight
700.81
References & Citations
[1]Banas V, et al. Inhibitors of membrane associated serine proteases block replication of coronavirus SARS-CoV-2 and influenza virus H1N1. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118385.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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