TriGalNAc CBz

• UNSPSC Description:

  TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies[1].

• Target Antigen:

  LYTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/trigalnac-cbz.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(C1=CC=CC=C1)O[C@H]2[C@H]([C@H](O[C@H]([C@@H]2NC(C)=O)OCCCCC(O)=O)COC(C3=CC=CC=C3)=O)OC(C4=CC=CC=C4)=O

• Molecular Weight:

  633.64

• References & Citations:

  [1]Kallanthottathil G. Rajeev, et al. Compositions and methods for targeted rna delivery. WO2021178725.|[2]Biessen EA, Sliedregt-Bol K, 'T Hoen PA, et al. Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepatocytes. Bioconjug Chem. 2002;13(2):295-302.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  186613-57-0