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EG01449

CAT: 0804-HY-179350ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179350ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EG01449 is a quinoline-based antagonist of Neuropilin-1 (NRP1) with an Kd of 0.6 µM.  EG01449 competitively inhibits the binding of VEGFA to NRP1 with  an IC50  of 362 nM. EG01449  prevents VEGFA-induced pain by inhibiting NRP1-dependent signaling and reducing sodium currents in sensory neurons. EG01449 can be used for the research of nociceptive pain[1].
UNSPSC
12352005
Target
VEGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C([C@H](CCCNC(N)=N)NC(C1=C(C=CS1)NS(=O)(C2=C3N=CC=CC3=CC(NCC4=CSC(N5CCNCC5)=N4)=C2)=O)=O)O.O=CO
Molecular Formula
C29H36N10O7S3
Molecular Weight
732.85
References & Citations
[1]Hestehave S, et al. Quinoline-Based Neuropilin‑1 Antagonists Exhibit a Pure Antagonist Profile and Block Vascular Endothelial Growth Factor-Induced Pain. ACS Pharmacol Transl Sci. 2025;8 (11) :3844-3871. Published 2025 Oct 29.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19274308-01EG01449
GTR19274966-01EG01449 Free acid

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