Products for Research Use Only

EG01449 Free acid

CAT: 0013-GTR19274966-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19274966-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
EG01449 Free acid is a quinoline-based antagonist of neuropilin-1 (NRP1), exhibiting a Kd of 0.6 μM. It competitively inhibits the binding of VEGFA to NRP1, with an IC50 of 362 nM. By inhibiting NRP1-dependent signaling and reducing sodium currents in sensory neurons, EG01449 Free acid prevents VEGFA-induced pain. Additionally, it is capable of crossing the blood-brain barrier, allowing for targeted effects within the central nervous system. EG01449 Free acid is applicable for pain research.
Storage Conditions
-20°C
Notes
For research use only.

Popular Products