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Trans-Thalidomide-1,4-cyclohexanediamine

CAT: 0804-HY-179306Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179306Size:1 Each
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Description
Trans-Thalidomide-1,4-cyclohexanediamine is a PROTAC E3 ligase-linker conjugate that can be used for synthesis of PROTACs, such as CL-F-B1. CL-F-B1 is a potent PD-L1 PROTAC degrader with anticancer activity[1].
CAS Number
2983442-53-9
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N(C(C2=C(C=CC=C21)N[C@@H]3CC[C@@H](N)CC3)=O)C4CCC(NC4=O)=O
Molecular Formula
C19H22N4O4
Molecular Weight
370.40
References & Citations
[1]Qi Q, et al. Rational Design of PROTAC Degraders and Their Spatiotemporal Controlled Delivery for Enhanced Tumor Penetration and PD-L1 Protein Degradation. J Med Chem. 2025 Nov 13;68 (21) :22665-22688.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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