IBI-325

• Target :

  TNF|||IFNAR|||Interleukin|||CD73

• Related Pathways :

  Apoptosis|||Immunology/Inflammation

• Bioactivity :

  IBI-325 is a humanized monoclonal antibody inhibitor targeting CD73. It completely inhibits CD73 enzymatic activity without causing a hook effect. IBI-325 can reverse adenosine monophosphate-mediated immunosuppression and significantly inhibits T cell proliferation and the release of cytokines (IL-2, IFN-?, and TNF-?) . In both hPBMC-reconstituted mouse models and hCD73 knock-in mouse models, IBI-325 demonstrates potent antitumor activity. This compound is applicable for cancer immunotherapy research.

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C