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IBI-325

CAT: 0931-T9901A-1902-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T9901A-1902-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
TNF, IFNAR, Interleukin, CD73
Related Pathways
Apoptosis, Immunology/Inflammation
Bioactivity
IBI-325 is a humanized monoclonal antibody inhibitor targeting CD73. It completely inhibits CD73 enzymatic activity without causing a hook effect. IBI-325 can reverse adenosine monophosphate-mediated immunosuppression and significantly inhibits T cell proliferation and the release of cytokines (IL-2, IFN-γ, and TNF-α) . In both hPBMC-reconstituted mouse models and hCD73 knock-in mouse models, IBI-325 demonstrates potent antitumor activity. This compound is applicable for cancer immunotherapy research.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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