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HDB-1

CAT: 0804-HY-179133Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179133Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDB-1 is a selective inhibitor of the P2Y14 receptor (P2Y14R) with an IC50 of 26 pM. HDB-1 shows no significant inhibition on P2Y1R, P2Y2R, P2Y4R, P2Y6R, and P2Y12R. HDB-1 blocks the activation of hepatic stellate cells (HSC) by inhibiting the PKA/Raf1/MEK/ERK signaling pathway mediated by P2Y14R, thereby alleviating the core pathological process of liver fibrosis. HDB-1 can be used for the study of liver fibrosis[1].
CAS Number
3021527-82-9
UNSPSC
12352005
Target
ERK; MEK; P2Y Receptor; PKA; Raf
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CC1=CC=C(C=C1)NC2=C(C(C2=O)=O)NC3=CC=C4N=COC4=C3
Molecular Formula
C18H13N3O3
Molecular Weight
319.31
References & Citations
[1]Li C, et al. Discovery of Novel P2Y14R Inhibitors for Ameliorating Liver Fibrosis by Suppressing Hepatic Stellate Cell Activation. J Med Chem. 2025 Nov 13;68 (21) :23277-23299.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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