APG-7

• Description :

  APG-7 binds to the TLR4/MD-2 interface, thereby inhibiting NO production (IC50 of 24.2 μg/mL) . APG-7 is an Apigenin (HY-N1201) derivative. APG-7 has low toxicity to the 3T3 fibroblast cell line. APG-7 can be used for the study of oxidative stress and inflammation[1].

• UNSPSC :

  12352005

• Target :

  Toll-like Receptor (TLR)

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Cancer; Metabolic Disease; Inflammation/Immunology

• Smiles :

  O[C@@H]1[C@@H](OC2=CC=C(C=C2)C3=CC(C4=C(C=C(C=C4O3)O)O)=O)O[C@@H](COC(/C=C/C5=CC=C(C=C5)O)=O)[C@H](O)[C@@H]1O

• Molecular Formula :

  C30H26O12

• Molecular Weight :

  578.52

• References & Citations :

  [1]Soomro S, et al. Apigenin and its derivative modulate nitric oxide production and interfere with TLR4-M2: In-vitro and in-silico insights. Bioorg Chem. Published online October 4, 2025.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TLR4