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BRAFV600E-IN-3

CAT: 0804-HY-178995Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178995Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BRAFV600E-IN-3 (Compound AV05) is a BRAFV600E inhibitor with an IC50 value of 0.89 μM. BRAFV600E-IN-3 inhibits the proliferation of melanoma cells. BRAFV600E-IN-3 can be used for the study of melanoma[1].
Target
Raf
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Smiles
O=S(C1=CC=CC=C1)(NC2=CC=C(C3NC(NC(C4=CC(Br)=CC=C4)=C3)=S)C=C2)=O
Molecular Formula
C22H18BrN3O2S2
Molecular Weight
500.43
References & Citations
[1]Singh AK, et al. Targeted design, synthesis, molecular simulation, ADME-T and in-vitro anticancer assessment of phenyl-substituted-thioxo-tetrahydro-pyrimidin-benzenesulfonamide derivatives as potential BRAFV600E/WT inhibitors. Bioorg Med Chem Lett. 2025 Oct 8;130:130431.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf

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