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BRAFV600E/ABL2-IN-1

CAT: 0804-HY-178382Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178382Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BRAFV600E/ABL2-IN-1 is a BRAFV600E (IC50 = 0.088 μM) /ABL2 (IC50 = 0.3 μM) dual inhibitor. BRAFV600E/ABL2-IN-1 can diminish P-glycoprotein expression. BRAFV600E/ABL2-IN-1 effectively inhibits p-CrkL (Abl2 signaling) and p-ERK1/2 (BRAFV600E pathway) in A375-R melanoma cells. BRAFV600E/ABL2-IN-1 causes cell cycle arrest at the G1 phase, inhibiting progression to the S phase and subsequent phases and G2/M phase. BRAFV600E/ABL2-IN-1 significantly increases the percentage of late apoptotic cells. BRAFV600E/ABL2-IN-1 can be used for the study of melanoma[1].
UNSPSC
12352005
Target
Apoptosis; Bcr-Abl; PERK; P-glycoprotein; Raf
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(N/N=C(C1=CC=C(Br)C=C1)\C)CN2C(C3=CC=C(S(=O)(C)=O)C=C3)=NC4=CC(Cl)=CC=C24
Molecular Formula
C24H20BrClN4O3S
Molecular Weight
559.86
References & Citations
[1]Badawy MAS, et al. Targeting melanoma resistance: Novel oxindole and non-oxindole-based benzimidazole derivatives as potent dual inhibitors of BRAFV600E and ABL2 kinases. Eur J Med Chem. 2025 Dec 15;300:118096.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf

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