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STK10-IN-1

CAT: 0804-HY-178974Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178974Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SLK/STK10-IN-2 (Compound 23) is a highly selective STK10 inhibitor, with a Kd of 365 nM and an IC50 of 0.85 μM. SLK/STK10-IN-2 exhibits EC50 of 0.89 μM in NanoBRET cell experiments. SLK/STK10-IN-2 shows no significant binding to SLK, STK3/4. SLK/STK10-IN-2 can be used to study STK10-related diseases (such as abnormal lymphocyte migration) [1].
UNSPSC
12352005
Target
Ser/Thr Kinase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CC1=CC(Cl)=CC=C1CNC(NC2=CC=C3C=C2OCCOCCNC4=NC5=C3C=NN5C=C4)=O
Molecular Formula
C25H25ClN6O3
Molecular Weight
492.96
References & Citations
[1]Dettenhöfer M, et al. Un-LOK-ing a New Approach for Conformational Selective Targeting of STK10 (LOK) . ACS Med Chem Lett. 2025 Oct 14;16 (11) :2086-2096.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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