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HJ-4

CAT: 0804-HY-178921-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-178921-02Size:10 mg
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Description
HJ-4 is a Piperine derivative. HJ-4 potently inhibits the proliferation of CRC cells by dose-dependently reducing colony formation and DNA synthesis. HJ-4 markedly suppresses the adhesion, migration, invasion and induces apoptosis of CRC cells. HJ-4 demonstrates anti-tumor efficacy in chicken embryo chorioallantoic membrane (CAM) model implanted with HCT116/SW480 tumor spheroids. HJ-4 can be used for the study of colorectal cancer (CRC).
CAS Number
1313741-00-2
UNSPSC
12352005
Target
Apoptosis; Drug Derivative
Related Pathways
Apoptosis; Others
Field of Research
Cancer
Purity
98.02
Smiles
COC1=CC=CC=C1N2CCN(CC2)C(/C=C/C=C/C3=CC4=C(OCO4)C=C3)=O
Molecular Formula
C23H24N2O4
Molecular Weight
392.45
References & Citations
[1]Zhang L, et al. HJ-4, a novel piperine derivative, inhibits tumor growth and angiogenesis via p53 activation and oncogenic pathway inhibition in colorectal cancer models. Sci Rep. 2025 Sep 29;15 (1) :33541.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-[4-(2-methoxyphenyl)piperazin-1-yl]penta-2,4-dien-1-one
CAS Number1313741-00-2
PubChem CID53303330
IUPAC Name(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-[4-(2-methoxyphenyl)piperazin-1-yl]penta-2,4-dien-1-one
Molecular FormulaC23H24N2O4
Molecular Weight392.4
XLogP3.8
Topological Polar Surface Area51.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count29
Formal Charge0
Complexity600
SMILES
COC1=CC=CC=C1N2CCN(CC2)C(=O)/C=C/C=C/C3=CC4=C(C=C3)OCO4
InChI
InChI=1S/C23H24N2O4/c1-27-20-8-4-3-7-19(20)24-12-14-25(15-13-24)23(26)9-5-2-6-18-10-11-21-22(16-18)29-17-28-21/h2-11,16H,12-15,17H2,1H3/b6-2+,9-5+
InChIKey
YJMIFRFZGOUBRN-VDESZNBCSA-N
Chemical Structure
2D Structure
2D structure of (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-[4-(2-methoxyphenyl)piperazin-1-yl]penta-2,4-dien-1-one
CAS: 1313741-00-2
CID: 53303330
Formula: C23H24N2O4
MW: 392.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight392.4
XLogP33.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass392.17360725
Monoisotopic Mass392.17360725
Topological Polar Surface Area51.2 Ų
Heavy Atom Count29
Formal Charge0
Complexity600
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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