HJ-4

• Description :

  HJ-4 is a Piperine (HY-N0144) derivative. HJ-4 potently inhibits the proliferation of CRC cells by dose-dependently reducing colony formation and DNA synthesis. HJ-4 markedly suppresses the adhesion, migration, invasion and induces apoptosis of CRC cells. HJ-4 demonstrates anti-tumor efficacy in chicken embryo chorioallantoic membrane (CAM) model implanted with HCT116/SW480 tumor spheroids. HJ-4 can be used for the study of colorectal cancer (CRC) [1].

• CAS Number :

  [1313741-00-2]

• UNSPSC :

  12352005

• Target :

  Apoptosis; Drug Derivative

• Related Pathways :

  Apoptosis; Others

• Field of Research :

  Cancer

• Purity :

  98.02

• Smiles :

  COC1=CC=CC=C1N2CCN(CC2)C(/C=C/C=C/C3=CC4=C(OCO4)C=C3)=O

• Molecular Formula :

  C23H24N2O4

• Molecular Weight :

  392.45

• References & Citations :

  [1]Zhang L, et al. HJ-4, a novel piperine derivative, inhibits tumor growth and angiogenesis via p53 activation and oncogenic pathway inhibition in colorectal cancer models. Sci Rep. 2025 Sep 29;15 (1) :33541.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported