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Copper ionophore I

CAT: 0804-HY-178914Size: 1 EachDry Ice: NoHazardous: No
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Description
Copper ionophore I is an efficient copper ion carrier. Copper ionophore I can regulate various intracellular copper levels to induce cuproptosis, such as 4T1 (IC50 = 0.45 μM) and MDA-MB-231 (IC50 = 1.21 μM) cells. Copper ionophore I can induce an increase in ROS and cause mitochondrial dysfunction. Copper ionophore I can reduce the expression of FDX1, DLAT, and LIAS proteins. Copper ionophore I can activate immune related pathways and promote T cell infiltration. Copper ionophore I can be used for cancer research[1].
CAS Number
101264-90-8
UNSPSC
12352005
Target
Cuproptosis; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
OC1=C(/C=N/NC(CCCCC)=O)C=CC=C1
Molecular Formula
C13H18N2O2
Molecular Weight
234.29
References & Citations
[1]Yu L, et al. Rational design of copper ionophores for efficient induction of cuproptosis via simple n-alkyl modification. Eur J Med Chem. 2026 Jan 5;301:118257.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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