TJN-331

CAT: 0804-HY-178850Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178850Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TJN-331 is a potent and orally active TGF-β1 Inhibitor. TJN-331 ameliorates anti-glomerular basement membrane (GBM) nephritis in rats by inhibitng TGF-β1 production, thereby reducing extracapillary proliferation in glomeruli. TJN-331 inhibits mesangial expansion in experimental IgA nephropathy in ddY mice. TJN-331 can be used for the research of nephritis and IgA nephropathy[1][2].
CAS Number
[219964-53-1]
UNSPSC
12352005
Target
TGF-β Receptor
Related Pathways
TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(/C=C/C1=CN=CC=C1)N(C)CCC2=CC(OC)=C(C=C2)OC
Molecular Formula
C19H22N2O3
Molecular Weight
326.39
References & Citations
[1]Saegusa Y, et al. TJN-331 improves anti-glomerular basement membrane nephritis by inhibiting the production of intraglomerular transforming growth factor-beta1. Biol Pharm Bull. 2010;33 (8) :1349-1354.|[2]Saegusa Y, et al. (E) -N-[ (3,4-dimethoxyphenethyl) ]-N-methyl-3- (3-pyridyl) -2-propenamide (TJN-331) inhibits mesangial expansion in experimental IgA nephropathy in ddY mice. Clin Exp Nephrol. 2010 Dec;14 (6) :528-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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