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JNK-IN-25

CAT: 0804-HY-178692Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178692Size:1 Each
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Description
JNK-IN-25 is a potent and selective  JNK1/2/3 inhibitor with IC50 values  of 1.54 (JNK1), 1.99  (JNK2), and 0.75 nM (JNK3), respectively. JNK-IN-25 inhibits phosphorylation of c-Jun in cells via covalently bonding with the conserved cysteine of JNK1/2/3. JNK-IN-25 can be used for research of  cancer, inflammatory and neurodegenerative diseases[1].
CAS Number
1644498-54-3
UNSPSC
12352005
Target
JNK
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Smiles
O=C(C1=CC(NC(/C=C/CN(C)C)=O)=CC=C1)NC(C=C2)=CC=C2NC3=NC=CC(C4=CN=CC=C4)=N3
Molecular Formula
C28H27N7O2
Molecular Weight
493.56
References & Citations
[1]Zhang T, et al. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012;19 (1) :140-154.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK1; JNK2; JNK3

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