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METTL3-IN-11

CAT: 0804-HY-178446Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178446Size:1 Each
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Description
METTL3-IN-11 is an excellent, selective METTL3 inhibitor (IC50 = 45.31 nM) . METTL3-IN-11 exhibits high selectivity towards METTL3 compared to DNMT1, EZH1, MLL1, and PRMT1. METTL3-IN-11 reduces the m6A level of total RNA in MOLM-13 and SKOV3 cells, induces cell apoptosis, and inhibits cell migration. METTL3-IN-11 can reduce the expression of m6A downstream target genes (c-MYC and BCL2) . METTL3-IN-11 can be used for the study of ovarian cancer and acute myeloid leukemia[1].
CAS Number
3069369-05-4
UNSPSC
12352005
Target
Bcl-2 Family; c-Myc; METTL3
Related Pathways
Apoptosis; Epigenetics
Field of Research
Cancer
Smiles
OC1=C(CN2C=NC(C(NCC3=CN4C(C=CC(CNCC5CCC5)=C4)=N3)=O)=CC2=O)C=CC=C1
Molecular Formula
C26H28N6O3
Molecular Weight
472.54
References & Citations
[1]Miao R, et al. Identification of novel 2, 6-Di-substituted Imidazo[1,2-a]pyridine derivatives as potent METTL3 inhibitors. Bioorg Chem. 2025 Oct;165:108980.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2

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