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METTL3-IN-11

CAT: 0013-GTR19273264-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273264-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
METTL3-IN-11 is a highly selective METTL3 inhibitor (IC50 = 45.31 nM), demonstrating greater selectivity for METTL3 over DNMT1, EZH1, MLL1, and PRMT1. It reduces m6A levels in total RNA of MOLM-13 and SKOV3 cells, inducing apoptosis and inhibiting migration. METTL3-IN-11 also decreases expression of m6A downstream target genes (c-MYC and BCL2) . It is applicable in ovarian cancer and acute myeloid leukemia research.
CAS Number
3069369-05-4
Smiles
O=C1C=C (N=CN1CC=2C=CC=CC2O) C (=O) NCC=3N=C4C=CC (=CN4C3) CNCC5CCC5
Molecular Formula
C26H28N6O3
Molecular Weight
472.55
Storage Conditions
-20°C
Notes
For research use only.

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