SHMT2-IN-1

• Description:

  SHMT2-IN-1 is a potent serine hydroxymethyltransferase 2 (SHMT2) inhibitor with an IC50 of 1.21 μM and a KD of 10.6 μM. SHMT2-IN-1 binds to the folate binding site of SHMT2. SHMT2-IN-1 also inhibits SHMT1 with an IC50 of 1.83 μM. SHMT2-IN-1 can inhibit cancer cells proliferation, migration and invasion. SHMT2-IN-1 can induce cells apoptosis and ROS production and cause G2/M phase arrest. SHMT2-IN-1 can be used for the research of cancer, such as esophageal cancer[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Reactive Oxygen Species (ROS) ; SHMT

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  N#CC1=C(N=C(N=C1C2=CC=C(C=C2)Cl)SCC3=CC=C(C=C3)C(O)=O)SC4=NN=NN4C5=CC=CC=C5

• Molecular Formula:

  C26H16ClN7O2S2

• Molecular Weight:

  558.03

• References & Citations:

  [1]Akram HMB, et al. Discovery of W478, a novel SHMT2 inhibitor for the treatment of esophageal carcinoma. Bioorg Chem. 2025 Oct;165:109028.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  SHMT1