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SHMT2-IN-1

CAT: 0013-GTR19273648-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273648-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SHMT2-IN-1 is a potent inhibitor of serine hydroxymethyltransferase 2 (SHMT2) with an IC50 of 1.21 μM and a KD of 10.6 μM. It binds to the folate binding site of SHMT2 and also inhibits SHMT1 with an IC50 of 1.83 μM. MT-44 can suppress the proliferation, migration, and invasion of cancer cells, inducing apoptosis and reactive oxygen species (ROS) production, leading to G2/M phase arrest. SHMT2-IN-1 is applicable in cancer research, including studies on esophageal cancer.
Storage Conditions
-20°C
Notes
For research use only.

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