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PFKFB4-IN-1

CAT: 0804-HY-178367Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178367Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PFKFB4-IN-1 is a potent and selective ATP-competitive PFKFB4 inhibitor (IC50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels. PFKFB4-IN-1 exhibits >12-fold selectivity over PFKFB1/4 and PFKFB3/4. PFKFB4-IN-1 inhibits cancer cell proliferation, induces apoptosis, and inhibits cell migration. PFKFB4-IN-1 inhibits tumor growth in the MDA-MB-231 xenograft mouse model. PFKFB4-IN-1 can be used for breast, lung and liver cancer research[1].
CAS Number
2664831-55-2
UNSPSC
12352005
Target
Apoptosis; Caspase; PARP; Phosphatase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=[N+](C1=CC=C(O1)/C=N\NC2=CC=C(C3=NON=C23)[N+]([O-])=O)[O-]
Molecular Formula
C11H6N6O6
Molecular Weight
318.20
References & Citations
[1]Chen Y, et al. Structure-guided discovery of nitrobenzo-2-oxa-1,3-diazole (NBD) scaffold-based PFKFB4 inhibitors for cancer therapy. Eur J Med Chem. 2025 Dec 15;300:118109.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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