T2M-010

• Description :

  T2M-010 is a potent, brain-penetrant TREM2 agonist (Kd = 0.83 μM) . T2M-010 activates receptor-proximal signaling, inducing SYK phosphorylation in TREM2-expressing cells, and promotes microglial phagocytosis. T2M-010 can be used for the study of protective microglial responses relevant to Alzheimer’s disease (AD) [1].

• UNSPSC :

  12352005

• Target :

  Syk; TREM receptor

• Related Pathways :

  Immunology/Inflammation; Protein Tyrosine Kinase/RTK

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Smiles :

  C1(CCNC2=NC(C3=CNC4=C3C=CC=C4)=CS2)=CC=CC=C1

• Molecular Formula :

  C19H17N3S

• Molecular Weight :

  319.42

• References & Citations :

  [1]Cho S, et al. AI-Assisted Discovery and Optimization of Small Molecule TREM2 Agonists with Functional Microglial Activity. bioRxiv [Preprint]. 2025 Sep 17:2025.09.11.675743.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [364611-21-2]