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E0199

CAT: 0804-HY-178281Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178281Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
E0199 is a novel potent dual-target KV7/NaV modulator that activates the KV7 channel (KV7.2/7.3 (EC50 = 12.78 nM), KV7.2 (EC50 = 0.50 μM), and KV7.5 (EC50 = 27.14 nM) channels) while simultaneously blocks the NaV1.7 (IC50 = 0.52 μM), NaV1.8 (IC50 = 0.24 μM), and NaV1.9 (IC50 = 0.16 μM) channels. E0199 shows a potent analgesic effect without affecting heart and skeletal muscle ion channels critically in a chronic constriction injury (CCI) mouse model. E0199 can be used for Neuropathic pain (NP) research[1].
CAS Number
931928-13-1
UNSPSC
12352005
Target
Potassium Channel; Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
COC1=C(C=CC(CC(N2CCN(CC2)CC3=NOC(CCC(N(CC4=CC=CC=C4)CC)=O)=N3)=O)=C1)OC
Molecular Formula
C29H37N5O5
Molecular Weight
535.63
References & Citations
[1]Zhang B, et al. Discovery of E0199: A novel compound targeting both peripheral NaV and KV7 channels to alleviate neuropathic pain. J Pharm Anal. 2025 Jan;15 (1) :101132.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.7; Nav1.8; Nav1.9

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CatalogName
GTR19273329-01E0199

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