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E0199

CAT: 0013-GTR19273329-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273329-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
E0199 is an innovative and potent KV7/NaV dual-target modulator that activates KV7 potassium channels, including KV7.2/7.3 (EC50 = 12.78 nM), KV7.2 (EC50 = 0.50 μM), and KV7.5 (EC50 = 27.14 nM), while inhibiting NaV1.7 (IC50 = 0.52 μM), NaV1.8 (IC50 = 0.24 μM), and NaV1.9 (IC50 = 0.16 μM) sodium channels. In a mouse model of chronic constriction injury (CCI) to the sciatic nerve, E0199 demonstrated potent analgesic effects without significant impact on cardiac and skeletal muscle ion channels. E0199 is applicable in studies related to neuropathic pain (NP) .
CAS Number
931928-13-1
Smiles
O=C (N1CCN (CC2=NOC (=N2) CCC (=O) N (CC=3C=CC=CC3) CC) CC1) CC4=CC=C (OC) C (OC) =C4
Molecular Formula
C29H37N5O5
Molecular Weight
535.65
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
HY-178281E0199

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