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SHY-855

CAT: 0804-HY-178194Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178194Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SHY-855 is a pan RAS inhibitor. SHY-855 effectively prevents the binding of K-Ras proteins and other members of the Ras superfamily of small GTPases with IC50 values of 0.3-5 μM. SHY-855 effectively inhibits the phosphorylation of MEK, ERK1/2, and AKT downstream of K-Ras. SHY-855 inhibits the formation of the Ras-GTP activity complex. SHY-855 can be used to the studies of pancreatic cancer and non-small cell lung cancer[1].
CAS Number
2446485-15-8
UNSPSC
12352005
Target
Akt; ERK; MEK; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COCCNC1=NC(C2=NC=CN2C)=NC3=C1C(C4=CC=CC=C4)=C(S3)C5=C(C(OC)=CC=C5)Cl
Molecular Formula
C26H24ClN5O2S
Molecular Weight
506.02
References & Citations
[1]Carta L, et al. Identification of Small-Molecule Inhibitors that Block the GTP-Binding Pocket of K-Ras and Other Members of the Ras Superfamily of Small GTPases. Mol Cancer Ther. 2025 Sep 12:OF1-OF10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt; ERK1; ERK2; K-Ras; MEK

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