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ETI41

CAT: 0804-HY-178166-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-178166-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ETI41 is an orally active, selective TLR inhibitor that targets the nucleoside-binding Site I on TLR7 (IC50 = 0.63 μM) and TLR9 (IC50 = 0.16 μM), sparing surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4 and TLR5) . ETI41 potently inhibits endosomal TLR-mediated pro-inflammatory signaling with nanomolar activity in cellular, biophysical and in vivo assays. ETI41 suppresses the expression of inflammation-associated genes and effectively ameliorates symptoms in mouse models of psoriasis, and systemic lupus erythematosus (SLE) . ETI41 can be used for autoimmune and inflammatory diseases research[1].
CAS Number
2773474-99-8
UNSPSC
12352005
Target
ERK; Interleukin Related; JNK; NF-κB; p38 MAPK; TNF Receptor; Toll-like Receptor (TLR)
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CC(N1CCCN(C)C)=CC(C1=N2)=C(N)C3=C2CCCCCC3
Molecular Formula
C19H30N4
Molecular Weight
314.47
References & Citations
[1]Jeong U, et al. Discovery of ETI41 and ETI41: novel selective endosomal Toll-like receptor inhibitors for the treatment of autoimmune diseases. Exp Mol Med. 2025 Sep;57 (9) :1951-1962.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
TLR7; TLR9

Chemical Information

4-[3-(Dimethylamino)propyl]-5-methyl-2,4-diazatricyclo[7.6.0.03,7]pentadeca-1(9),2,5,7-tetraen-8-amine
CAS Number2773474-99-8
PubChem CID163381632
IUPAC Name4-[3-(dimethylamino)propyl]-5-methyl-2,4-diazatricyclo[7.6.0.03,7]pentadeca-1(9),2,5,7-tetraen-8-amine
Molecular FormulaC19H30N4
Molecular Weight314.5
XLogP3.6
Topological Polar Surface Area47.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity372
SMILES
CC1=CC2=C(C3=C(CCCCCC3)N=C2N1CCCN(C)C)N
InChI
InChI=1S/C19H30N4/c1-14-13-16-18(20)15-9-6-4-5-7-10-17(15)21-19(16)23(14)12-8-11-22(2)3/h13H,4-12H2,1-3H3,(H2,20,21)
InChIKey
SWJRKISLPFBTSS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-[3-(Dimethylamino)propyl]-5-methyl-2,4-diazatricyclo[7.6.0.03,7]pentadeca-1(9),2,5,7-tetraen-8-amine
CAS: 2773474-99-8
CID: 163381632
Formula: C19H30N4
MW: 314.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight314.5
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass314.24704697
Monoisotopic Mass314.24704697
Topological Polar Surface Area47.1 Ų
Heavy Atom Count23
Formal Charge0
Complexity372
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
GTR19273561-01ETI41

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