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ETI41

CAT: 0013-GTR19273561-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273561-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ETI41 is an orally active selective TLR inhibitor that targets the nucleoside-binding site I of TLR7 (IC50= 0.63 μM) and TLR9 (IC50= 0.16 μM), without affecting surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4, and TLR5) . It demonstrates nanomolar activity in cell-based, biophysical, and in vivo studies, effectively inhibiting endosomal TLR-mediated pro-inflammatory signaling. ETI41 suppresses the expression of inflammation-related genes and significantly improves symptoms in mouse models of psoriasis and systemic lupus erythematosus (SLE) . ETI41 is applicable in research related to autoimmune and inflammatory diseases.
CAS Number
2773474-99-8
Smiles
N=1C2=C (C=C (N2CCCN (C) C) C) C (N) =C3C1CCCCCC3
Molecular Formula
C19H30N4
Molecular Weight
314.48
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
HY-178166-01ETI41

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