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SARS-CoV-2 PLpro-IN-3

CAT: 0804-HY-179293Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179293Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SARS-CoV-2 PLpro-IN-3 (Compound 15) is a covalent inhibitor of the SARS-CoV-2 papain-like protease (PLpro), with an IC50 of 25 nM. SARS-CoV-2 PLpro-IN-3 has similar inhibitory activity against SARS-CoV PLpro (IC50 = 59 nM), but shows no inhibitory effect on human ubiquitin-specific protease 7 (USP7) . The EC50 of SARS-CoV-2 PLpro-IN-3 in inhibiting SARS-CoV-2 replication in cells is 96 nM, significantly reducing the viral titer and viral RNA levels. SARS-CoV-2 PLpro-IN-3 can be used for studying SARS-CoV-2 drug resistance mutations[1].
UNSPSC
12352005
Target
SARS-CoV; Virus Protease
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(N[C@@H](C1=C2C=CC=CC2=CC=C1)C)C3=CC=CC=C3CCC(NNC(/C=C/C(NC4=CC=CN=C4)=O)=O)=O
Molecular Formula
C31H29N5O4
Molecular Weight
535.59
References & Citations
[1]Garad DN, et al. Targeting the S1' Pocket of SARS-CoV‑2 Papain-Like Protease Yields Highly Potent Inhibitors. ACS Med Chem Lett. 2025 Oct 30;16 (11) :2280-2285.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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