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FB231

CAT: 0804-HY-178154Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178154Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FB231 is a Parkin activator. FB231 can induce mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response. FB231 can lower the threshold for mitochondrial toxins to induce PINK1/Parkin-mediated mitophagy. FB231 can cause activation of the integrated stress response (ISR) and perturbation to iron-dependent pathways. FB231 can be used for the research of neurological disease, such as Parkinson’s disease[1].
CAS Number
2166045-37-8
UNSPSC
12352005
Target
Mitochondrial Metabolism; PINK1/Parkin
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC1=C(C=CC=C1)C(NC2=NN(C(NC(C3=C(C=CC=C3)C)=O)=N2)C4=CC=CC=C4)=O
Molecular Formula
C24H21N5O2
Molecular Weight
411.46
References & Citations
[1]Rosencrans WM, et al. Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress. Sci Adv. 2025 Aug 29;11 (35) :eady0240.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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