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FB231

CAT: 0804-HY-178154Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178154Size:1 Each
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Description
FB231 is a Parkin activator. FB231 can induce mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response. FB231 can lower the threshold for mitochondrial toxins to induce PINK1/Parkin-mediated mitophagy. FB231 can cause activation of the integrated stress response (ISR) and perturbation to iron-dependent pathways. FB231 can be used for the research of neurological disease, such as Parkinson’s disease[1].
CAS Number
2166045-37-8
UNSPSC
12352005
Target
Mitochondrial Metabolism; PINK1/Parkin
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC1=C(C=CC=C1)C(NC2=NN(C(NC(C3=C(C=CC=C3)C)=O)=N2)C4=CC=CC=C4)=O
Molecular Formula
C24H21N5O2
Molecular Weight
411.46
References & Citations
[1]Rosencrans WM, et al. Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress. Sci Adv. 2025 Aug 29;11 (35) :eady0240.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-[1-Phenyl-5-(o-toluoylamino)-1H-1,2,4-triazol-3-yl]-o-toluamide
CAS Number2166045-37-8
PubChem CID132191027
IUPAC Name2-methyl-N-[5-[(2-methylbenzoyl)amino]-1-phenyl-1,2,4-triazol-3-yl]benzamide
Molecular FormulaC24H21N5O2
Molecular Weight411.5
XLogP4.7
Topological Polar Surface Area88.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity623
SMILES
CC1=CC=CC=C1C(=O)NC2=NN(C(=N2)NC(=O)C3=CC=CC=C3C)C4=CC=CC=C4
InChI
InChI=1S/C24H21N5O2/c1-16-10-6-8-14-19(16)21(30)25-23-27-24(29(28-23)18-12-4-3-5-13-18)26-22(31)20-15-9-7-11-17(20)2/h3-15H,1-2H3,(H2,25,26,27,28,30,31)
InChIKey
CYPQMMPJIOIHAQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[1-Phenyl-5-(o-toluoylamino)-1H-1,2,4-triazol-3-yl]-o-toluamide
CAS: 2166045-37-8
CID: 132191027
Formula: C24H21N5O2
MW: 411.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight411.5
XLogP34.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass411.16952493
Monoisotopic Mass411.16952493
Topological Polar Surface Area88.9 Ų
Heavy Atom Count31
Formal Charge0
Complexity623
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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