FB23

• Description :

  FB23 is a potent and selective FTO demethylase inhibitor with an IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity[1].

• UNSPSC :

  12352005

• Target :

  Fat Mass and Obesity-associated Protein (FTO)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/fb23.html

• Concentration :

  10mM

• Purity :

  98.88

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(O)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)ON=C3C)C=C2Cl

• Molecular Formula :

  C18H14Cl2N2O3

• Molecular Weight :

  377.22

• References & Citations :

  [1]Yue Huang, et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019 Apr 15;35 (4) :677-691.e10.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2243736-35-6]