FB23

• Description:

  FB23 is a potent and selective FTO demethylase inhibitor with an IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity[1].

• UNSPSC:

  12352005

• Target:

  Fat Mass and Obesity-associated Protein (FTO)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/fb23.html

• Concentration:

  10mM

• Purity:

  98.88

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C (O) C1=CC=CC=C1NC2=C (Cl) C=C (C3=C (C) ON=C3C) C=C2Cl

• Molecular Formula:

  C18H14Cl2N2O3

• Molecular Weight:

  377.22

• References & Citations:

  [1]Yue Huang, et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019 Apr 15;35 (4) :677-691.e10.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2243736-35-6