FB23-2

• Description:

  FB23-2 is a potent and selective inhibitor of mRNA N6-methyladenosine (m6A) demethylase FTO, with an IC50 of 2.6 μM. FB23-2 has anti-proliferation activity. FB23-2 can be used for the research of acute myeloid leukemia (AML) [1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/fb23-2.html

• Concentration:

  10mM

• Purity:

  99.93

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O=C(NO)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)ON=C3C)C=C2Cl

• Molecular Formula:

  C18H15Cl2N3O3

• Molecular Weight:

  392.24

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Huang Y, et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019 Apr 15;35 (4) :677-691.e10.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2243736-45-8