Products for Research Use Only
RegisterLogin

JNJ-78911118

CAT: 0804-HY-178121-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-178121-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
JNJ-78911118 is a potent, brain-penetrant, selective GluN2A antagonist (IC50 = 44 nM) . JNJ-78911118 shows >200-fold selectivity against GluN1/2B, 2C and 2D receptors. JNJ-78911118 functions as a negative allosteric modulator (NAM) by insurmountably suppressing glutamate efficacy and reducing glycine potency at GluN1/2A receptors. JNJ-78911118 produces profound pharmacodynamic effects in vivo. JNJ-78911118 can be used for depression research[1].
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Neurological Disease; Inflammation/Immunology
Purity
99.38
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=NC(C(NCC2=CC=CN=C2)=O)=CN=C1OCC(F)(F)C3=CC(Cl)=CC=N3
Molecular Formula
C19H16ClF2N5O2
Molecular Weight
419.81
References & Citations
[1]Lord B, et al Pharmacological characterisation of JNJ-78911118, a novel, centrally-penetrant, selective GluN2A antagonist. Br J Pharmacol. 2025 Sep;182 (17) :4080-4102.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NMDA Receptor

Related Products

CatalogName
HY-172194JNJ-3738
HY-P991172JNJ-70218902
HY-113751-01JNJ-39393406
HY-132895JNJ-67569762
HY-118424-01JNJ-55511118
HY-110132-01JNJ-27141491
HY-19917-01JNJ-39220675
HY-123531JNJ 10329670
HY-148240-01JNJ-65355394
HY-111066-01JNJ-37822681

Alternative Products

CatalogName
GTR19273813-01JNJ-78911118
MBS131356JNJ-63533054 (JNJ63533054; JNJ 63533054)
BA6861-10JNJ-42253432
A4361-50JNJ-1661010
BA6753-5.1JNJ-61432059
BA6849-10JNJ-55308942
C4122-10JNJ-42165279
BA5559-5.1JNJ-40411813
B5553-5JNJ 10397049
B1574-10JNJ-7777120

Popular Products