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α4β7 Integrin-IN-1

CAT: 0804-HY-177961Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-177961Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
α4β7 Integrin-IN-1 (Example 356) is a potent inhibitor of α4β7 integrin (integrin) . Its ability to block the interaction between α4β7 integrin and MadCAM-1 (EC50) is 0.05 nM. α4β7 Integrin-IN-1 can be used for the study of inflammatory bowel disease[1].
CAS Number
2417307-52-7
UNSPSC
12352005
Target
Integrin
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CN(C(N1C2=CC=C(C3=C2N=CC=C3)C[C@H](NC(C(C(F)=C4)=C(C)C=C4N5CCOC[C@@H]5C(F)(F)F)=O)C(O)=O)=O)C6=CN=CC=C6C1=O
Molecular Formula
C33H28F4N6O6
Molecular Weight
680.61
References & Citations
[1]Peter A, et al. Quinoline derivatives as alpha4beta7 integrin inhibitors. WO2020092375A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α4β7

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