BTT-3034

• Description:

  BTT-3034, a sulfonamide derivative, is an α2β1 integrin inhibitor. BTT-3034 inhibits cell adhesion to rat tail collagen I with an EC50 of 160 nM and a corresponding Emaxof 86%. BTT-3034 inhibits collagen binding by an α2 variant carrying the conformationally activating E318W mutation[1].

• UNSPSC:

  12352100

• Target:

  Integrin

• Related Pathways:

  Cytoskeleton

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C(NC1=CC=C(N(S(=O)(C2=CC=C(C3=CC=NN3C)S2)=O)C)C=C1)NC4=CC=CC=C4

• Molecular Formula:

  C22H21N5O3S2

• Molecular Weight:

  467.56

• References & Citations:

  [1]Nissinen L, et al. Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J Biol Chem. 2012 Dec 28;287 (53) :44694-702.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1259029-47-4]