BTT-3034

CAT: 0804-HY-177331Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-177331Size:1 Each
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Description
BTT-3034, a sulfonamide derivative, is an α2β1 integrin inhibitor. BTT-3034 inhibits cell adhesion to rat tail collagen I with an EC50 of 160 nM and a corresponding Emaxof 86%. BTT-3034 inhibits collagen binding by an α2 variant carrying the conformationally activating E318W mutation[1].
CAS Number
[1259029-47-4]
UNSPSC
12352100
Target
Integrin
Related Pathways
Cytoskeleton
Field of Research
Cardiovascular Disease
Smiles
O=C(NC1=CC=C(N(S(=O)(C2=CC=C(C3=CC=NN3C)S2)=O)C)C=C1)NC4=CC=CC=C4
Molecular Formula
C22H21N5O3S2
Molecular Weight
467.56
References & Citations
[1]Nissinen L, et al. Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J Biol Chem. 2012 Dec 28;287 (53) :44694-702.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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