KAT6A/KAT7-IN-1

• Description :

  KAT6A/KAT7-IN-1 (Example 113) is a KAT6A and KAT7 inhibitor. The IC50 of KAT6A/KAT7-IN-1 for KAT6A is > 1 nM but ≤ 10 nM, while the IC50 for KAT7 is ≤ 1 nM. KAT6A/KAT7-IN-1 can inhibit the acetylation of H3K14 and H3K23. KAT6A/KAT7-IN-1 also inhibits tumor cell proliferation, with an IC50 of > 2 μM but ≤ 5 μM for CAMA-1. KAT6A/KAT7-IN-1 can be used in the study of cancer[1].

• UNSPSC :

  12352005

• Target :

  Histone Acetyltransferase

• Related Pathways :

  Epigenetics

• Field of Research :

  Cancer

• Smiles :

  O=S(C1=C(OC)C=CC=C1OC)(NC2=NOC3=C2CC4(C5=C3C=C(N6C(CCC6)=O)C=C5)CC4)=O

• Molecular Formula :

  C25H25N3O6S

• Molecular Weight :

  495.55

• References & Citations :

  [1]Brian Thomas Jones, et al. Chemical compounds and uses thereof. WO2025136811A1. 2025-06-26.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported