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ALG-001075

CAT: 0804-HY-177022-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-177022-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALG-001075, a capsid assembly modulator (CAM), is an orally active HBV inhibitor. ALG-001075 effectively blocks not only HBV DNA production but also extracellular HBsAg/HBeAg and intracellular HBV RNA in primary human hepatocytes. ALG-001075 shows pronounced reductions of circulating HBV DNA in the AAV-HBV mouse model. ALG-001075 can be used for the study of Chronic hepatitis B (CHB) [1].
CAS Number
2495324-66-6
UNSPSC
12352005
Target
HBV
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Purity
98.82
Solubility
DMSO : 70 mg/mL (ultrasonic)
Smiles
N#CC1=CC(NC(C2=C(C)C(C(C(NC3(COC3)C#C)=O)=O)=C(C)N2C)=O)=CC=C1F
Molecular Formula
C22H19FN4O4
Molecular Weight
422.41
References & Citations
[1]Vendeville S, et al. The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075. J Med Chem. 2024 Dec 12;67 (23) :21126-21142.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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