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LATS-IN-2

CAT: 0804-HY-176886-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-176886-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LATS-IN-2 is an efficiently acting LATS (large tumor suppressor kinase) inhibitor. LATS-IN-2 shows potent inhibitory activity against LATS1 with an IC50 value of 1.3 nM. LATS-IN-2 suppresses the phosphorylation of YAP by inhibiting LATS kinase activity. LATS-IN-2 increases the thickness of the epidermis in mice. LATS-IN-2 can be used for the study of ocular diseases such as limbal stem cell deficiency and corneal endothelial dysfunction[1].
CAS Number
2248728-49-4
UNSPSC
12352005
Target
YAP
Related Pathways
Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Others
Purity
99.4500
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1(CC1)NC2=NC(C3=CNN=C3C)=NC4=C2C=CN=C4
Molecular Formula
C15H16N6
Molecular Weight
280.33
References & Citations
[1]BEHNKE, Dirk, et al. 6-6 FUSED BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS LATS INHIBITORS. WO 2018/198077 A2. World Intellectual Property Organization (WIPO) . 01 November 2018.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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