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LATS1/2-IN-1

CAT: 0804-HY-175649Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175649Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LATS1/2-IN-1 is a potent and selective LATS1 and LATS2 inhibitor. LATS1/2-IN-1 exhibits potent inhibitory activity against LATS1 and LATS2 with IC50 values of 4.4 nM and 5.5 nM as determined via r33P functional assay. LATS1/2-IN-1 displays cellular IC50 values of 136 nM for LATS1 and 36.0 nM for LATS2 as determined via NanoBRET assay. LATS1/2-IN-1 reduces phosphorylation of YAP1 in mouse liver. LATS1/2-IN-1 demonstrates wound healing activity in HT-1080 scratch assay and in vivo SKH1 mouse punch biopsy model. LATS1/2-IN-1 can be used for the study of regenerative medicine indications such as wound healing[1].
CAS Number
3024011-99-9
UNSPSC
12352100
Target
YAP
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=S1(CCC(N2C[C@@H](C)[C@](O)(C3=C(C)C=C(C4=C5C(NC=C5F)=NC=C4)C=C3F)[C@@H](C)C2)CC1)=O
Molecular Formula
C26H31F2N3O3S
Molecular Weight
503.60
References & Citations
[1]Morris PJ, et al. Discovery and Optimization of LATS1 and LATS2 Kinase Inhibitors for Use in Regenerative Medicine. J Med Chem. 2025 Aug 28;68 (16) :17499-17515.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
YAP1

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