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Nebivolol O-β-D-glucuronide

CAT: 0804-HY-176333Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176333Size:1 Each
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Description
Nebivolol O-β-D-glucuronide is a derivative of Nebivolol. Nebivolol is an orally active beta receptor blocker and has the high beta (1) -receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease[1][2][3].
UNSPSC
12352005
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Cardiovascular Disease
Smiles
FC1=CC=C2C(CCC([H])(O2)C(CNCC(C3(CCC4=C(O3)C=CC(F)=C4)[H])O)O[C@]5([C@@H]([C@H]([C@@H]([C@H](O5)C(O)=O)O)O)O)[H])=C1
Molecular Formula
C28H33F2NO10
Molecular Weight
581.56
References & Citations
[1]Vieira CP, et al. An indirect stereoselective analysis of nebivolol glucuronides in plasma by LC-MS/MS: Application to clinical pharmacokinetics. J Pharm Biomed Anal. 2017 Sep 10;144:25-30. |[2]Thomas Münzel, et al. Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol. 2009 Oct 13;54 (16) :1491-9.|[3]Brehm BR, et al. Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res. 2001 Feb 1;49 (2) :430-9
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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