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DA-NHbenzylOCF3

CAT: 0804-HY-176217-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-176217-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DA-NHbenzylOCF3 is a DNA-targeted radiosensitizer that enhances the sensitivity of tumor cells to X-rays through the dissociative electron attachment (DEA) mechanism. dA-NHbenzylOCF3 has low toxicity to normal cells and is mainly localized in the cytoplasm and nucleus after entering the cell. dA-NHbenzylOCF3 exerts radiosensitization effects by inducing cell cycle arrest in the radiosensitive G2/M phase. dA-NHbenzylOCF3 can be used for radiosensitization studies of malignant tumors such as prostate cancer and breast cancer[1].
UNSPSC
12352005
Target
Biochemical Assay Reagents; DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Purity
98.04
Smiles
O[C@H]1C[C@@H](O[C@@H]1CO)N2C(NCC3=CC=C(OC(F)(F)F)C=C3)=NC4=C(N=CN=C42)N
Molecular Formula
C18H19F3N6O4
Molecular Weight
440.38
References & Citations
[1]Datta M, et al. Substituted benzylamino-2'-deoxyadenosine a modified nucleoside with radiosensitizing properties. Sci Rep. 2025 May 20;15 (1) :17535.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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